In budding yeast, inhibition of assembly is brought on by Cdk-dependent phosphorylation of pre-replication complicated factors. In the onset of S phase, phosphorylation of Cdc6 by Cdk1 results in the binding of Cdc6 to the SCF ubiquitin protein ligase, which results in proteolytic destruction of Cdc6. Cdk-dependent phosphorylation of Mcm https://arthurpgyju.life-wiki.com/314057/gene_synthesis_companies_can_be_fun_for_anyone