Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts within the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, ... https://mannersq887ixm4.wiki-cms.com/user